By Lipka J.
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Extra resources for [Article] Motion on a Surface for any Positional Field of Force
Academic Press, San Diego. 14. Ushiro, H. and Cohen, S. (1980). Identiﬁcation of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes. J. Biol. Chem. 255, 8363–8365. This Page Intentionally Left Blank PART I Initiation: Extracellular and Membrane Events James A. Wells, Editor This Page Intentionally Left Blank PART I Introduction James A. Wells Cells within multicellular organisms communicate via extracellular mediators: either through diffusible molecules or by direct cell–cell contact.
The latter receptor class can be referred to as horizontal because ligand binding ﬁrst facilitates lateral association (or change in association) of receptor subunits. This causes a change in the juxtaposition of the intracellular domains of the receptor and induces further association with intracellular signaling molecules. These receptor classes have very different evolutionary origins and cellular roles. The vertical receptors, covered in Section B, contain multiple membrane-crossing segments and are found in all organisms from bacteria to eukaryotes.
The complication in predicting the role of electrostatic interactions is that they generally reﬂect a balance between two large and opposing forces. For example, the formation of an ion pair as a result of complex formation requires that both charges be removed from the solvent and be completely or partially buried at an interface. For a completely buried ion pair, the loss of solvation is believed to be a larger effect than the gain of Coulomb energy in the complex so that individual ion pairs and hydrogen bonds are believed to oppose complex formation.